APIS®

Collagen + Manuka honey like never before, now for chronic wounds.

 

APIS® is an affordable prescription treatment proven to deliver leading closure results in chronic and acute wounds, including diabetic ulcers.

  • APIS® is a bioengineered wound product made with a collagen derivative, Manuka honey, and hydroxyapatite. FDA-cleared for the management of chronic and acute wounds, APIS® covers and protects the wound, absorbs exudate, and creates a moist wound environment. In vitro data demonstrates that APIS® reduces bacterial load [4], decreases MMP-9 [5], and triggers the release of growth factors [5], which has been shown to instill balance in the wound microenvironment and progress the wound towards healing.

  • Covered by CMS, APIS® is FDA-cleared for the management of a variety of wounds, featuring:

    • 2x faster wound closure (4 to 8 weeks) [1, 2, 3]

    • Powerful microenvironment support [4, 5, 6]

    • Convenient absorbable sheet

    • Mess-free application

    • Cost-effective

  • Under the supervision of a healthcare professional, APIS® is indicated for use in management of wounds, including:

    • Full and partial thickness wounds

    • Pressure ulcers (stages I-IV)

    • Venous stasis ulcers

    • Diabetic ulcers

    • Surface wounds

    • Traumatic wounds (healing by secondary intention)

    • Surgical wounds 

    • Abrasions

    • Donor site wounds

 

  • 1. Rodriguez, et al. 2023.

    Novel bioengineered collagen + Manuka honey + hydroxyapatite sheet for the treatment of lower extremity chronic wounds in an urban hospital wound care setting.

    2. Rodriguez, et al. 2020.

    Preliminary clinical evaluation of a novel bioengineered wound product: A focus on the management of lower extremity ulcers.

    3. McMurray, et al. 2021.

    Use of a Novel Biomaterial to Enhance Secondary Intention Healing. Available Wound Products: Collagen Sheet, Manuka Honey Sheet, and a Novel Bioengineered Collagen Derivative + Manuka Honey + Hydroxyapatite Sheet.

    4. Williams, et al. 2021.

    A novel bioengineered wound product with in vitro capabilities to reduce bacteria.

    5. Rodriguez, et al. 2021.

    Microenvironment influence of a novel bioengineered wound product APIS®: An in vitro analysis of inflammatory marker and growth factor secretion.

    6. Rodriguez, et al. 2022.

    A Preliminary Direct Comparison of the Inflammatory Reduction and Growth Factor Production Capabilities of Three Commercially Available Wound Products: Collagen Sheet, Manuka Honey Sheet, and a Novel Bioengineered Collagen Derivative + Manuka Honey + Hydroxyapatite Sheet.

“My patients are doing unbelievably well and healing after the first application, which in a chronic wound is just such a rarity to see.”

— Physician with experience using 50+ applications of APIS®

APIS® is simple to use

Clean

Prepare

Apply + Cover

 

Want to learn more? Reach out.